Cited by R. Stockman and E.D.W. Greig, 'The Action of Arsenic on the Bone-Marrow and Blood', Journal of Physiology 23 (5) (1898), pp. 376-382.
Description:

Explanation of Plate V (figs.1-6):

'1. Normal bone-marrow from upper end of femur of young rabbit, x 60 diams. It shows numerous fat cells (the white spaces), marrow-cells, and two large blood-vessels in centre of field, but few elsewhere.

2. Bone-marrow from upper end of femur of young rabbit after administration of arsenic for 60 days, x 60 diams. It shows the numerous blood-vessels, marrow-cells increased in number, very few fat cells and these distinctly atrophied. There is a large blood-vessel on left-hand side of figure.

3. Same as Fig. 1 x 300 diams. It shows numerous large fat cells, marrow-cells, a myelocyte, eosinophil cells, and some ted blood-corpuscles.

4. Same as Fig. 2 x 3000 diams. It shows the blood-vessels greatly increased and filled with corpuscles, numerous marrow-cells, one myelocyte, fat cells few and atrophied, and eosinophil cells.

5. Normal bone-marrow from middle of femur of adult rabbit, x 60 diams. It shows very numerous fat cells, marrow- cells, and a few small blood-vessels.

6. Bone-marrow from middle of femur of adult rabbit after administration of arsenic for 125 days. It shows increase in number and size of bloodvessels, decrease in number and size of fat cells, more numerous marrow-cells.' (382)

 

Figs. I-IV [1-4] in text:

'Description of the Bone-marrow. The structure of normal bone-marrow from a young rabbit is shown in Figs. I. and III., under a low and higher power of the microscope respectively. It is made up of numerous large fat cells, very few capillaries, and ordinary nucleated marrow cells with a few red blood corpuscles free among them. An occasional large myelocyte is seen and a few eosinophil cells. Figs. II. and IV. show the appearance of the marrow in our rabbits which received arsenic. The difference is extremely striking, especially in the great increase in the number and size of the capillary vessels, which are distended with red blood corpuscles. There is also a much larger number of red corpuscles free among the marrow cells. The fat cells are much smaller and have to a large extent disappeared. The marrow cells also are greatly increased in number and are more closely packed together, this being allowed by the great diminiution in the amount of fat. Under a higher power the fat cells which remain are seen to be small, and have an atrophied look. The large marrow cells in many instances contain bodies which seem to be red blood corpuscles, and several eosinophil cells are present in the field.' (379)

 

Figs. V-VI [5-6] in text:

'In the arsenic rabbit the bone-marrow was somewhat more red than in the control, but the difference was not so marked as in the young animals. On microscopic examination, however, the same changes were seen as in the others, and are shown by comparing Figs. V. and VI. The changes are not so decided as in younger animals, but the increase in the blood supply and in the number of marrow cells and the decrease in the amount of fat are quite unmistakable. There is, in short, here also, evidence of very considerable stimulation of the marrow.' (380)