W. Rees Wright- No links match your filters. Clear Filters
-
CreatedW. Yorke and W. Rees Wright, ‘The Mosquito Infectivity of P. Vivax After Prolonged Sojourn in the Human Host,‘ Annals of Tropical Medicine and Parasitology, 20 (3) (1926), pp. 327-328.
1926
Description:‘In the now extensive literature relating to the malaria treatment of general paralysis, the statement is not infrequently encountered that maintenance in the human host for prolonged periods, by direct inoculation of infective blood from one individual to another, modifies the malaria parasite in certain important respects.
...
In previous papers (Yorke and Macfie, 1924, and Yorke, 1925) reference is made to the fact that a strain of Plasmodium vivax maintained by direct passage in the human host since September, 1922 -partly at Whittingham, and partly at Sheffield, mental hospitals - was still capable of infecting A. maculipennis at various passages up to the forty-first.
In March, 1926, after the strain had been maintained in the human host for three and a half years, its capacity to infect A. maculipennis was again examined. Forty-seven mosquitos were allowed to feed three times on a patient of the fifty-third passage, and once on a patient of the fifty-fourth passage. Fifteen days after the first feed, the mosquitos were divided into four groups, each of which was fed on a general paralytic; all four patients became infected [327-328] with malaria. Twenty-three of the mosquitos, which lived for longer than a week after the first feed, were dissected, and of these nineteen were found to be infected-three with oocysts only, and sixteen with sporozoites in the salivary glands.
This observation shows that the strain in question had preserved unimpaired its power to infect mosquitos after fifty-three or fifty-four direct passages through man during a period of three and a half years.’ (327-328)
-
Cited byW. Yorke and J.W.S. Macfie, 'Observations on Malaria made During Treatment of General Paralysis,' Transactions of the Royal Society of Tropical Medicine and Hygiene 18 (1-2) (1924), pp. 13-33.
Description:On adoption of mosquitoes as transmitters (NB: blood transfusion ruled out due to familial objections) between patients at Whittingham Mental Hospital: ‘For a number of reasons, [note: ‘The relatives of a number of cases objected to the inoculation of infective blood from G.P.I. patients.’] which we need not discuss here, it was considered desirable to infect certain patients by the bite of mosquitoes instead of by direct inoculation of infective blood. The mosquitoes used were mainly A. maculipennis, for a constant supply of which we are greatly indebted to Mr Rees Wright, B.Sc., of the Department of Zoology, University College, Bangor, who collected the hibernating females mainly in farm buildings in Carnarvonshire, and who has sent us, from 11th October, 1923, to the end of April, 1924, about 2,000 mosquitoes. During August, September, and the early part of October, 1923, before we began to receive a regular supply of A. maculipennis from Mr. Wright, we used A. maculipennis and A. bifurcatus reared from larvae collected in Cheshire.' (16)
-
Cited byW. Yorke, ‘The Malaria Treatment of General Paralysis,’ Nature 114 (25th Oct. 1924), pp. 615-616.
Description:'For various reasons it was decided in a number of instances to modify the mode of infecting the patient, and, instead of producing the disease by the inoculation of malaria blood, to do so by Nature's method; i.e. by the bite of infective mosquitoes. The mosquitoes used were two commonly found in Great Britain, namely, Anopheles maculipennis and Anopheles bifurcatus, and for a constant supply of the former we are greatly indebted to Mr. Rees Wright, of the Department of Zoology, University College, Bangor, who during the winter collected the hibernating females in farm buildings in Carnarvonshire.' (615)
Links
Menu
